[Alpha]-sheet: The toxic conformer in amyloid diseases?
Article Abstract:
An analysis is conducted to determine that association of conformational changes and amyloidosis results in the formation of [alpha]-sheet and it symbolizes the toxic conformer. The structural properties of the [alpha]-sheet, background information, and experimental support of this unique structure recognized through molecular dynamics simulations of different protein related with amyloid diseases under amyloidogenic conditions are described along with the role of the conformation in the diseases.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
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Metal ion modulated electron transfer in photosynthetic proteins
Article Abstract:
The role of protein metal sites in enforcing protein structure, metal ion storage, dioxygen binding, electron transfer and catalysis is discussed. Metal ion binding to the reaction center (RC) can affect primary photochemistry and provides a probe for understanding the involvement of local protein environments in electron transfer.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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Reactions of the diiron enzyme stearoyl-acyl carrier protein desaturase
Article Abstract:
The reactions of the multiprotein diiron enzyme complex with stearoyl-acyl carrier protein are discussed. The changes in diiron enzymes in electronic configuration at metal centers are carried out by spectroscopic methods.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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